5-Amino-1MQ vs MOTS-C vs SLU-PP-332
5-Amino-1MQ, MOTS-C, and SLU-PP-332 are three of the most-discussed compounds in modern metabolic research. They target completely different molecular targets - NNMT, AMPK, and ERR (estrogen-related receptor) respectively - but appear together in research focused on metabolic enhancement, adipose tissue, and exercise mimetics. This three-way comparison clarifies how they differ.
| Property | 5-Amino-1MQ | MOTS-C | SLU-PP-332 |
|---|---|---|---|
| Compound type | Small-molecule NNMT inhibitor | 16-aa mitochondrial peptide | Small-molecule ERR agonist |
| Primary target | NNMT enzyme | AMPK pathway | ERR alpha/beta/gamma receptors |
| Research focus | Adipose, NAD+ pathways | Mitochondrial, glucose | Exercise mimetic, fat oxidation |
| Origin | Synthetic methylquinolinium | Encoded in mitochondrial DNA | Synthetic ERR agonist |
| Stage of research | Active preclinical | Active preclinical | Emerging, fewer studies |
About 5-Amino-1MQ
5-Amino-1-methylquinolinium is a small-molecule inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT). NNMT is highly expressed in adipose tissue, and research has explored whether its inhibition affects NAD+ availability and adipocyte metabolism. Research has characterized 5-Amino-1MQ for effects on adipose mass and metabolic markers in animal models.
About MOTS-C and SLU-PP-332
MOTS-C is a 16-amino acid peptide encoded within mitochondrial DNA, investigated primarily for AMPK pathway activation and glucose handling. SLU-PP-332 is a synthetic small-molecule agonist of the estrogen-related receptor (ERR) family, investigated as an exercise mimetic in animal models with research focused on fat oxidation and endurance. SLU-PP-332 is the newest of the three and has the least published research history.
Which Should Researchers Choose?
The choice depends on the molecular target of interest:
- NNMT inhibition or adipose tissue research -> 5-Amino-1MQ.
- AMPK or mitochondrial peptide research -> MOTS-C.
- Exercise-mimetic or ERR-receptor research -> SLU-PP-332.
These compounds are not interchangeable in research design - each targets a distinct pathway.
Shop these compounds
Frequently Asked Questions
Can these three be researched together?
Some research protocols investigate combinations since they target completely separate pathways.
Which has the most research history?
MOTS-C and 5-Amino-1MQ both have established preclinical research; SLU-PP-332 is more recent and has less published characterization.
Are these FDA approved?
No. All three are investigational research compounds not approved for human consumption.