What is Slu-PP-332?
Slu-PP-332 is a synthetic compound studied in metabolic research as an agonist of the estrogen-related receptors (ERRs). It has attracted research interest as a candidate "exercise mimetic" — a compound investigated for whether it can activate some of the same metabolic pathways associated with physical exercise.
Unlike peptides that act on cell-surface receptors, Slu-PP-332 is studied for its activity on the ERR family of nuclear receptors, which are associated with mitochondrial function and energy metabolism.
This article is intended as a scientific overview for laboratory researchers. All compounds discussed are sold strictly for in-vitro research and are not for human consumption.
Discovery and Background
Slu-PP-332 emerged from research into ERR agonism as a way to study the metabolic adaptations associated with exercise. The estrogen-related receptors are studied for their role in regulating genes involved in mitochondrial biogenesis and oxidative metabolism.
Mechanism of Action
Slu-PP-332's proposed mechanism centers on ERR agonism. By activating estrogen-related receptors, research literature examines whether it increases expression of genes associated with mitochondrial biogenesis, fatty acid oxidation, and oxidative energy metabolism — pathways that overlap with the adaptations studied in exercise research. This is why it is frequently described in research as an exercise-mimetic candidate.
Research Applications
Slu-PP-332 is examined in preclinical and in-vitro research including mitochondrial biogenesis studies, metabolic and exercise-mimetic research, fatty acid oxidation models, and analytical characterization. For related mitochondrial compounds, see our MOTS-C overview and SS-31 overview.
Laboratory Handling and Storage
Slu-PP-332 is supplied in lyophilized form. Store sealed, dry, and protected from light; -20°C is recommended for long-term storage. Slu-PP-332 is a hydrophobic small molecule (PubChem computes an XLogP3 of 3.7), not a peptide, so the solvent and stock concentration are chosen by the laboratory method rather than assumed to be water. Keep prepared stocks cold and protected from light, and minimize freeze-thaw cycles. Verify purity documentation before use; see how peptide purity is verified.
Research-Grade Slu-PP-332
In our catalog, Slu-PP-332 is available as Slu-PP-332, supplied as a lyophilized powder and third-party tested for purity. Lab reports (COAs) are listed by product and batch on our lab reports page as they become available; check it for a report matching the batch.
Sold strictly for in-vitro laboratory research. Not for human or animal consumption. This material has not been evaluated by the FDA.
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