What is Epithalon?
Epithalon (also spelled Epitalon) is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly. It was developed based on the study of a naturally occurring pineal gland peptide, and is investigated in research literature primarily in the context of telomere biology and cellular aging.
Epithalon is one of the more prominent peptides in longevity research, where it is studied for its proposed influence on telomerase activity.
This article is intended as a scientific overview for laboratory researchers. All compounds discussed are sold strictly for in-vitro research and are not for human consumption.
Discovery and Background
Epithalon was derived from research on Epithalamin, a natural peptide complex from the pineal gland studied in Russian research institutes. Investigators synthesized the short peptide sequence as a defined, reproducible research compound.
Mechanism of Action
Epithalon's proposed mechanism centers on telomerase, the enzyme associated with maintaining the protective telomere caps at the ends of chromosomes. Research literature examines whether Epithalon influences telomerase activity and, by extension, telomere length in cellular models — a question of significant interest in aging research. It is also studied in connection with circadian and pineal-related pathways, reflecting its origin.
Research Applications
Epithalon is examined in preclinical and in-vitro research including telomere and telomerase studies, cellular senescence and aging models, circadian rhythm research, and analytical characterization. For a related longevity-focused molecule, see our overview of NAD+.
Laboratory Handling and Storage
Epithalon is supplied in lyophilized (freeze-dried) form. Store the lyophilized powder sealed, dry, and protected from light; -20°C is generally recommended for long-term storage. Reconstitute with bacteriostatic water using appropriate dilution calculations for the intended experimental concentration — see our reconstitution guide for detailed ratios. Once reconstituted, store at 2-8°C and minimize freeze-thaw cycles, which contribute to peptide degradation. Verify purity and identity documentation before use; see our overview of how peptide purity is verified.
Research-Grade Epithalon
In our catalog, Epithalon is available as Epithalon, supplied as a lyophilized powder and third-party tested for purity. Certificates of Analysis are available for every batch on our COA page.
Sold strictly for in-vitro laboratory research. Not for human or animal consumption. This material has not been evaluated by the FDA.